INFLUENCE OF DIFFERENT TYPES OF ANESTHESIA FOR LAPAROSCOPIC HYSTERECTOMY ON THE DYNAMICS OF STRESS HORMONES

The aim of the study – to evaluate influence different variants anesthesia, including low-opioid (LOA) and opioid-free anesthesia (OFA), on dynamics stress response during laparoscopic hysterectomy.
 Materials methods: 102 patients were randomly allocated into 3 groups: 37 women assigned receive a standard opioid-based (OBA group), 33 LOA group 32 OFA group.
 Results: after induction intubation trachea showed significant (p<0.05) increase in cortisol level by 155.4 % 160.9 compared with OBA group. After completion hysterectomy, regardless variant exceeded preoperative one (pOBA=0.116, pLOA=0.049, pOFA=0.043). Two hours surgery group) there was further concentration blood, exceeding initial values 142.9 (p=0.043). Patients tended decrease cortisolemia. changes adrenaline & glucose levels somewhat similar.
 Conclusion: Use is accompanied an aggravation at stage which manifested cortisol. most adequate perioperative protection inherent lower release hormones hysterectomy postoperative period. Opioid-based provides intraoperative protection, but insufficient analgesia.